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Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study

By Michael Keane, BMBS, FANZCA and Shashikanth Manikappa, MD, DNB, FANZCA
February 21, 2019

Patient safety requires a well-informed debate about the rationale of large, randomized controlled trials (RCTs) and whether, by their very nature, they can adequately consider the unique physiology of every individual patient. 

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WAKE-UP Time for Thrombolysis in Acute Stroke?

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By Martina McGrath, MD
October 30, 2018

MRI thrombolysis for stroke of unknown time of onset

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Prior studies have suggested a particular pattern may be seen on an MRI of the brain in the early hours following stroke onset; a visible ischemic lesion on diffusion-weighted imaging along with the lack of a hyperintense signal in the same area on fluid-attenuated inversion recovery (FLAIR). The benefit of aggressive stroke intervention in patients with the combination of unknown time of symptom onset and this particular signal mismatch on MRI brain scans is unknown. Continue reading “WAKE-UP Time for Thrombolysis in Acute Stroke?”

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By Olivier Lucar
October 16, 2018

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Cannelure Mèche Set - 1.3cm D Paquet de 6 Pièce Numéro 4939 par Laser - Neuf

By Connor Emdin
September 26, 2018

Compression Tester Adaptor Laser Part No 3781 NewCondor Knife CTK105454C 60018 Two Rivers SkinnerConnect Part No 30771 NewConnect Part No 32513 New Continue reading “Use of Guideline-Recommended Medical Therapy in Patients with Heart Failure”

Restrictive versus Liberal Fluid Therapy in Abdominal Surgery

By Connor Emdin
August 28, 2018

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Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?

By Martina McGrath, MD
August 8, 2018

It is estimated that 1 in every 7.5 people in the US will die of sudden cardiac death.Capri Tools 3 4-Inch Drive Impact Extension Bar Set, CrMo, 3-Piece Survival following out-of-hospital cardiac arrest has increased in recent years, from 10.2% in 2006, to 12.4% in 2015.1 However, only 9% of those surviving to hospital discharge were classified as having good functional status. Therefore, significant long-term neurologic impairment is a common outcome of cardiac arrest. Continue reading “Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?”

Cervical Cancer Screening Using HPV Testing Alone: Are We There Yet?

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By Martina McGrath, MD
July 18, 2018

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Brand New 301 Piece Mechanic's Tool Set Kit Shop Garage Repair nbqvtm2326-Hand Tool Sets

Item specifics

Condition:
New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is ... Read moreabout the condition
Type: Mechanics Tool Set
Brand:

Pittsburgh

MPN:

63464

UPC:

Does not apply

Dulaglutide in Type 2 Diabetes: Do GLP-1 agonists delay progression of diabetic nephropathy?

Carlsto Carstoe BE CU Copper Beryllium Non-sparking 7 16 3 8 open end spanner

By Connor Emdin
June 27, 2018

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Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?

Case of 24 Mechanical In-Wall Timers, 15A 711AA UL Listed 1000W Tungsten 1 3 HP

By Martina McGrath, MD
June 5, 2018

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Craftsman 450PC Mechanics Tool Set with 3 Drawer Tool Box Chest Garage 450 Piece

By Lea Borgi, MD
May 16, 2018

Craftsman 6 8 10 12 Adjustable Wrench Set, made in USA - 4 pcsCraftsman 8 Wrenches 22985 Metric Combination Ratchetng 8 10 12 13 14 15 18mmCraftsman 9-37310 3 in 1 AccuCut Continue reading “Does Menu Labeling Lead to Healthier Food Choices?”