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Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study

By Michael Keane, BMBS, FANZCA and Shashikanth Manikappa, MD, DNB, FANZCA
February 21, 2019

Patient safety requires a well-informed debate about the rationale of large, randomized controlled trials (RCTs) and whether, by their very nature, they can adequately consider the unique physiology of every individual patient. 

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WAKE-UP Time for Thrombolysis in Acute Stroke?

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By Martina McGrath, MD
October 30, 2018

MRI thrombolysis for stroke of unknown time of onset

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Prior studies have suggested a particular pattern may be seen on an MRI of the brain in the early hours following stroke onset; a visible ischemic lesion on diffusion-weighted imaging along with the lack of a hyperintense signal in the same area on fluid-attenuated inversion recovery (FLAIR). The benefit of aggressive stroke intervention in patients with the combination of unknown time of symptom onset and this particular signal mismatch on MRI brain scans is unknown. Continue reading “WAKE-UP Time for Thrombolysis in Acute Stroke?”

NHT Center Channel Speaker L5

By Olivier Lucar
October 16, 2018

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Nice Boston Acoustics A225C (A Series) Center Channel Speakers - Pro Tested

By Connor Emdin
September 26, 2018

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Restrictive versus Liberal Fluid Therapy in Abdominal Surgery

By Connor Emdin
August 28, 2018

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Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?

By Martina McGrath, MD
August 8, 2018

It is estimated that 1 in every 7.5 people in the US will die of sudden cardiac death.Niles Audio PAIR of AT-8500 In Wall Speakers LOT130112200507 Survival following out-of-hospital cardiac arrest has increased in recent years, from 10.2% in 2006, to 12.4% in 2015.1 However, only 9% of those surviving to hospital discharge were classified as having good functional status. Therefore, significant long-term neurologic impairment is a common outcome of cardiac arrest. Continue reading “Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?”

Cervical Cancer Screening Using HPV Testing Alone: Are We There Yet?

Niles OS7.5 Indoor Outdoor Loudspeaker; 7-in. Carbon Woofer 2-Way (Pair)

By Martina McGrath, MD
July 18, 2018

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New Creative Labs Speaker 51MF0415AA002 Inspire T3300 2.1 Speaker System Retail nbwqoj5812-Home Speakers & Subwoofers

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Model Number: 51MF0415AA002




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Dulaglutide in Type 2 Diabetes: Do GLP-1 agonists delay progression of diabetic nephropathy?

NOGA NG9500 Platinum Box Set INCLUDES 1 Double burr.1 NG-1 & 1 NG-3 handle.1 ...

By Connor Emdin
June 27, 2018

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Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?

Norbar NOR15004 Pro 200 Adjustable Mushroom Head Torque Wrench 1 2in Drive 40-20

By Martina McGrath, MD
June 5, 2018

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Pair PDMN48 5'' 2-Way Bass Reflex Mini-Monitor & Bookshelf wall mount Speakers

By Lea Borgi, MD
May 16, 2018

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